I don't know how experienced you are. It is better to have too small a grip than too large, that is what most shooters find I believe. I agree that IF it is your wife's primary, taking into account, her hands are smaller, a larger grip 'MAY" make it difficult for her, or maybe not. The grip panels are not necessarily larger overall but shaped different to adjust the finger length from the trigger the back of the grip I believe, that is how the medium grip feels to me. I shot over 1200 rounds with the small grip, and have not shot the medium yet, as my range time last weekend went to pot, as I had to deal with a medical situation at the range; some fell and injured themselves. Even though I am retired, once a first responder, always one, eh?I have the small insert on our shared P10, due to my wife using it as her primary pistol. The first few outings, I was all over the place and immediately chalked it up to the grip being too small for me. Yesterday I went to the range and shot both the P10 and my P01 (shoot that one well), after paying very close attention to my trigger finger and how it was reacting, I was able to at least equal my results with the P01, if anything I do prefer the std sights on the P10. I think it’s really a mind over matter issue for me, I proved to myself that I was able to get rounds to go where I wanted despite that niggling “grip is too small” excuse in the back of my mind. Having said that, one of these days on another solo range trip, I will change it to one of the larger sizes and see if that does indeed make any difference. I must say that I’m very pleased to have shot P10 well, and am glad I didn’t give up on it in it’s current configuration.
You earned that , don't pretend it didn't make you happy.I have round 1200 rounds through my CZ P-10 C with the small grip installed as it came from CZ. Yesterday I moved to the medium grip, ready for shooting this weekend. It feels good in the hand, but, and there always is a but in life, that doesn't mean much in a static state. Only after putting rounds downrange, quickly, slowly, both hands and on target will the feeling part of shooting it becomes positive feedback to decide on keeping or dumping it. As an inveterate old-school shooter, I trust nothing to chance or the opine of others; I find my way to the best of the best for me.
There is no way to recommend a grip size, as it would be tantamount to telling another what size shoes to wear. Although it would be interesting to know which size grip is the most popular in the group of owners of the CZ P-10 C, although again, some will not even try other grip panels, and some are so new they don't know the difference as long as it shoots well, and that is all good as well.
I will report back on how the grip performed, excellent or not so much!
NOTE: Someone has issued, sent, or whatever, "Trophies" to me. I am old school, and A trophy for everybody is not for me, as I have earned enough on my own! Thanks for the kind thought, but don't bother on my account.